| Gene Information | |
|---|---|
| Gene Name | CLCN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 898 |
| Protein Names | Chloride channel protein 2 (ClC-2) |
| Target Name | chloride channel protein 2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000114859 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P51788 |
| Gene Card | CLCN2 |
| Uniprot ID | P51788 |
| Pfam | PF00654 |
| In ASD | no |
| Allosteric Prediction | yes (0.450082474) |
| Ortholog in Animals | Alpaca_ CLCN2 ( ortholog_one2one ) Dog_ CLCN2 ( ortholog_one2one ) GuineaPig_ CLCN2 ( ortholog_one2one ) Macaque_ CLCN2 ( ortholog_one2one ) Mouse_ Clcn2 ( ortholog_one2one ) Pig_ CLCN2 ( ortholog_one2one ) Rat_ Clcn2 ( ortholog_one2one ) Rabbit_ CLCN2 ( ortholog_one2one ) |
| Ohnologs | CLCN1, CLCNKB, CLCNKA |
| Paralogs | CLCN6, CLCN3, CLCN5, CLCNKB, CLCNKA, CLCN1, CLCN7, CLCN4 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Moderately expressed in aortic and coronary vascular smooth muscle cells and expressed at a low level in aortic endothelial cells. Expressed in the adrenal gland, predominantly in the zona glomerulosa (PubMed:29403011). {ECO:0000269|PubMed:10198195, ECO:0000269|PubMed:29403011}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs758379595 rs1085307938 rs1553857113 rs115661422 rs61729156 rs1293789661 rs863225248 rs71318369 rs587777111 rs137852682 rs148545588 rs115961753 rs9820367 rs137852681 rs2228292 rs138573287 rs114702742 rs144164281 rs1553853557 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:29403011}; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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