| Gene Information | |
|---|---|
| Gene Name | CLC |
| Organism | Homo sapiens (Human) |
| Gene Length | 142 |
| Protein Names | Galectin-10 (Gal-10) (Charcot-Leyden crystal protein) (CLC) (Eosinophil lysophospholipase) (Lysolecithin acylhydrolase) |
| Target Name | galectin-10 |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000105205 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q05315 |
| Gene Card | CLC |
| Uniprot ID | Q05315 |
| Pfam | PF00337 |
| In ASD | no |
| Allosteric Prediction | no (-0.617061932) |
| Ortholog in Animals | Pig_ LGALS13 ( ortholog_one2one ) Rabbit_ CLC ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LGALSL, GRIFIN, LGALS7, LGALS7B, LGALS3, LGALS1, LGALS4, LGALS12, LGALS8, LGALS2, LGALS13, LGALS14, LGALS16, LGALS9B, LGALS9, LGALS9C |
| Tissue | bone.marrow, whole.blood |
| Tissue Specificity | Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level). {ECO:0000269|PubMed:17502455, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:19758173, ECO:0000269|PubMed:22880030}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1G86 (X-ray 1.80A ) 1HDK (X-ray 1.80A ) 1LCL (X-ray 1.80A ) 1QKQ (X-ray 1.80A ) 5XRG (X-ray 1.55A ) 5XRH (X-ray 1.55A ) 5XRI (X-ray 1.68A ) 5XRJ (X-ray 1.90A ) 5XRK (X-ray 1.70A ) 5XRL (X-ray 2.00A ) 5XRM (X-ray 2.00A ) 5XRN (X-ray 1.60A ) 5XRO (X-ray 1.60A ) 5XRP (X-ray 2.00A ) 5YT4 (X-ray 2.00A ) 6A1S (X-ray 1.63A ) 6A1T (X-ray 1.97A ) 6A1U (X-ray 1.62A ) 6A1V (X-ray 1.98A ) 6A1X (X-ray 1.99A ) 6A1Y (X-ray 1.63A ) 6GKQ (X-ray 2.30A ) 6GKS (X-ray 1.38A ) 6GKT (X-ray 2.10A ) 6GKU (X-ray 1.91A ) 6GLW (X-ray 1.90A ) 6GLX (X-ray 3.40A ) 6L64 (X-ray 2.08A ) 6L67 (X-ray 1.97A ) 6L68 (X-ray 1.92A ) 6L6A (X-ray 1.81A ) 6L6B (X-ray 1.80A ) 6L6C (X-ray 1.77A ) 6L6D (X-ray 1.93A ) 6QRN (X-ray 1.40A ) |
| DBSNP | rs17608 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:17502455}. Cytoplasmic granule {ECO:0000269|PubMed:17502455}. Note=Localized in granules from where it may be secreted or transported to other locations in the cell. |
| Mouse PG classification | NA |
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