Gene Information
Gene NameCLASP1
OrganismHomo sapiens (Human)
Gene Length1538
Protein NamesCLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1)
Target Nameclip-associating protein 1
Target TypeNA
Gene Age810 ( ENSG00000074054 )
Evolutionary StageEukaryota
AlphaFoldDBQ7Z460
Gene CardCLASP1
Uniprot IDQ7Z460
PfamPF12348
In ASDno
Allosteric Predictionyes (0.211225484)
Ortholog in AnimalsAlpaca_ CLASP1 ( ortholog_one2one )
Dog_ CLASP1 ( ortholog_one2one )
GuineaPig_ CLASP1 ( ortholog_one2one )
Macaque_ CLASP1 ( ortholog_one2one )
Mouse_ Clasp1 ( ortholog_one2one )
Pig_ CLASP1 ( ortholog_one2one )
Rat_ Clasp1 ( ortholog_one2one )
Rabbit_ CLASP1 ( ortholog_one2one )
OhnologsCLASP2
ParalogsTOGARAM2, CLASP2, TOGARAM1
Tissuecerebellum, middle.temporal.gyrus
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4K92  (X-ray  2.00A  6MQ5  (X-ray  2.15A  6MQ7  (X-ray  1.78A 
DBSNP rs17761055 
Subcellular location [CC]Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network {ECO:0000305}. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.
Mouse PG classificationNA
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