Gene Information | |
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Gene Name | CLASP1 |
Organism | Homo sapiens (Human) |
Gene Length | 1538 |
Protein Names | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) |
Target Name | clip-associating protein 1 |
Target Type | NA |
Gene Age | 810 ( ENSG00000074054 ) |
Evolutionary Stage | Eukaryota |
AlphaFoldDB | Q7Z460 |
Gene Card | CLASP1 |
Uniprot ID | Q7Z460 |
Pfam | PF12348 |
In ASD | no |
Allosteric Prediction | yes (0.211225484) |
Ortholog in Animals | Alpaca_ CLASP1 ( ortholog_one2one ) Dog_ CLASP1 ( ortholog_one2one ) GuineaPig_ CLASP1 ( ortholog_one2one ) Macaque_ CLASP1 ( ortholog_one2one ) Mouse_ Clasp1 ( ortholog_one2one ) Pig_ CLASP1 ( ortholog_one2one ) Rat_ Clasp1 ( ortholog_one2one ) Rabbit_ CLASP1 ( ortholog_one2one ) |
Ohnologs | CLASP2 |
Paralogs | TOGARAM2, CLASP2, TOGARAM1 |
Tissue | cerebellum, middle.temporal.gyrus |
Tissue Specificity | NA |
Pharmacological Animal Models | NA |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 4K92 (X-ray 2.00A ) 6MQ5 (X-ray 2.15A ) 6MQ7 (X-ray 1.78A ) |
DBSNP | rs17761055 |
Subcellular location [CC] | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network {ECO:0000305}. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2. |
Mouse PG classification | NA |
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