| Gene Information | |
|---|---|
| Gene Name | MSLN |
| Organism | Homo sapiens (Human) |
| Gene Length | 630 |
| Protein Names | Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form] |
| Target Name | mesothelin |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000102854 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q13421 |
| Gene Card | MSLN |
| Uniprot ID | Q13421 |
| Pfam | PF06060 |
| In ASD | no |
| Allosteric Prediction | no (-0.428411363) |
| Ortholog in Animals | Alpaca_ MSLN ( ortholog_one2one ) GuineaPig_ MSLN ( ortholog_one2one ) Macaque_ MSLN ( ortholog_one2one ) Mouse_ Msln ( ortholog_one2one ) Rat_ Msln ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MSLNL, STRC, OTOA |
| Tissue | oviduct, lung, greater.omentum |
| Tissue Specificity | Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). {ECO:0000269|PubMed:16857795, ECO:0000269|PubMed:7665620}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4F3F (X-ray 2.65A ) 7U8C (X-ray 1.74A ) |
| DBSNP | rs9927389 rs17850474 rs35935235 rs1135210 |
| Subcellular location [CC] | Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.; [Megakaryocyte-potentiating factor]: Secreted.; [Isoform 3]: Secreted. |
| Mouse PG classification | NA |
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