| Gene Information | |
|---|---|
| Gene Name | PRSS5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 699 |
| Protein Names | Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P48740 |
| Gene Card | MASP1 |
| Uniprot ID | P48740 |
| Pfam | PF00431; PF00084; PF00089 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Protein of the plasma which is primarily expressed by liver. {ECO:0000269|PubMed:11485744, ECO:0000269|PubMed:8018603, ECO:0000269|PubMed:8240317, ECO:0000269|PubMed:9367419}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3DEM (X-ray 2.30A ) 3GOV (X-ray 2.55A ) 4AQB (X-ray 4.20A ) 4DJZ (X-ray 3.20A ) 4IGD (X-ray 2.50A ) 4IW4 (X-ray 3.20A ) 4KKD (X-ray 2.60A ) 7PQO (X-ray 3.39A ) |
| DBSNP | rs1062049 rs13322090 rs3774266 rs759368047 rs387906752 rs779329363 rs387906753 rs387906754 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:11485744}. |
| Mouse PG classification | NA |
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