| Gene Information | |
|---|---|
| Gene Name | CKB |
| Organism | Homo sapiens (Human) |
| Gene Length | 381 |
| Protein Names | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) |
| Target Name | creatine kinase b-type |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000166165 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P12277 |
| Gene Card | CKB |
| Uniprot ID | P12277 |
| Pfam | PF00217; PF02807 |
| In ASD | no |
| Allosteric Prediction | yes (0.518698638) |
| Ortholog in Animals | Alpaca_ CKB ( ortholog_one2one ) Dog_ CKB ( ortholog_one2many ) GuineaPig_ CKB ( ortholog_one2one ) Macaque_ CKB ( ortholog_one2one ) Mouse_ Ckb ( ortholog_one2one ) Pig_ CKB ( ortholog_one2one ) Rat_ Ckb ( ortholog_one2one ) |
| Ohnologs | CKM |
| Paralogs | CKM, CKMT1B, CKMT1A, CKMT2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3B6R (X-ray 2.00A ) 3DRB (X-ray 2.00A ) 3DRE (X-ray 2.20A ) 6V9H (EM 4.10A ) 7BF1 (X-ray 1.24A ) |
| DBSNP | rs36002620 rs35156510 rs12505 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04447}. Mitochondrion {ECO:0000250|UniProtKB:Q04447}. Note=Localizes to the mitochondria of thermogenic fat cells via the internal MTS-like signal (iMTS-L) region. {ECO:0000250|UniProtKB:Q04447}. |
| Mouse PG classification | NA |
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