| Gene Information | |
|---|---|
| Gene Name | CKAP5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2032 |
| Protein Names | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000175216 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14008 |
| Gene Card | CKAP5 |
| Uniprot ID | Q14008 |
| Pfam | PF12348 |
| In ASD | no |
| Allosteric Prediction | no (-0.072777619) |
| Ortholog in Animals | Alpaca_ CKAP5 ( ortholog_one2one ) Dog_ CKAP5 ( ortholog_one2one ) GuineaPig_ CKAP5 ( ortholog_one2one ) Macaque_ CKAP5 ( ortholog_one2one ) Mouse_ Ckap5 ( ortholog_one2one ) Pig_ CKAP5 ( ortholog_one2one ) Rat_ Ckap5 ( ortholog_one2one ) Rabbit_ CKAP5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Expression is elevated in the brain; highly expressed in the Purkinje cell bodies of the cerebellum. {ECO:0000269|PubMed:8536682, ECO:0000269|PubMed:8832653}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.120165(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4QMI (X-ray 1.90A ) 4QMJ (X-ray 2.50A ) |
| DBSNP | rs11038988 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:25596274, ECO:0000269|PubMed:9570755}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:21646404}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:25596274, ECO:0000269|PubMed:9570755}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:25596274}. Note=Detected on centrosomes and kinetochores during interphase and mitosis independently from TACC3 and clathrin. Located to spindle poles and microtubules during mitosis. In complex with TACC3 localized to microtubule plus-ends in mitosis and interphase. In complex with TACC3 and clathrin localized to inter-microtubule bridges in mitotic spindles. Accumulation sites at microtubule plus ends protruded approximately 100 nm from MAPRE1/EB1 sites in interphase cells. {ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23251535, ECO:0000269|PubMed:25596274}. |
| Mouse PG classification | NA |
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