| Gene Information | |
|---|---|
| Gene Name | CITED4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 184 |
| Protein Names | Cbp/p300-interacting transactivator 4 (MSG1-related protein 2) (MRG-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000179862 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q96RK1 |
| Gene Card | CITED4 |
| Uniprot ID | Q96RK1 |
| Pfam | PF04487 |
| In ASD | no |
| Allosteric Prediction | no (-1.166848422) |
| Ortholog in Animals | Alpaca_ CITED4 ( ortholog_one2one ) Dog_ CITED4 ( ortholog_one2one ) GuineaPig_ CITED4 ( ortholog_one2one ) Macaque_ CITED4 ( ortholog_one2one ) Mouse_ Cited4 ( ortholog_one2one ) Rat_ Cited4 ( ortholog_one2one ) Rabbit_ CITED4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CITED2, CITED1 |
| Tissue | NA |
| Tissue Specificity | Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal muscle and pancreas. Also expressed in bladder cell line ECV-304 and in various breast cancer cell lines. Also detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth and angiogenesis. {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}. Cytoplasm {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}. |
| Mouse PG classification | NA |
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