Gene Information
Gene NameCIB2
OrganismHomo sapiens (Human)
Gene Length187
Protein NamesCalcium and integrin-binding family member 2 (Kinase-interacting protein 2) (KIP 2)
Target Namecalcium and integrin-binding family member 2
Target TypeNA
Gene Age168 ( ENSG00000136425 )
Evolutionary StageEukaryota
AlphaFoldDBO75838
Gene CardCIB2
Uniprot IDO75838
PfamPF13499
In ASDno
Allosteric Predictionno (-0.867150656)
Ortholog in AnimalsAlpaca_ CIB2 ( ortholog_one2one )
Dog_ CIB2 ( ortholog_one2one )
GuineaPig_ CIB2 ( ortholog_one2one )
Macaque_ CIB2 ( ortholog_one2one )
Mouse_ Cib2 ( ortholog_one2one )
Pig_ CIB2 ( ortholog_one2one )
Rabbit_ CIB2 ( ortholog_one2one )
OhnologsCIB3, CIB1
ParalogsCIB1, CIB4, CHP1, CIB3, TESC, PPP3R1, CHP2, PPP3R2
Tissueleft.atrium
Tissue SpecificityWidely expressed (PubMed:23023331). {ECO:0000269|PubMed:23023331}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs145415848  rs780168150  rs758743502  rs397515411  rs370965183  rs397515412  rs370359511 
Subcellular location [CC]Cytoplasm {ECO:0000250|UniProtKB:Q9Z309}. Cell projection, stereocilium {ECO:0000269|PubMed:26173970, ECO:0000269|PubMed:26426422}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9Z309}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9Z309}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q9Z309}. Note=Colocalizes with ITGA7 at the myotendinous junctions (MTJ) and at the neuromuscular junctions (NMJ) (By similarity). Located mainly in stereocilia and at the apical surface of hair cells of the cochlea (By similarity). Localizes in the cuticular plate along and at the tip of the stereocilia of vestibular sensory hair cells (PubMed:26173970, PubMed:26426422). {ECO:0000250|UniProtKB:Q9Z309, ECO:0000269|PubMed:26173970, ECO:0000269|PubMed:26426422}.
Mouse PG classificationLPG
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