| Gene Information | |
|---|---|
| Gene Name | CIB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 191 |
| Protein Names | Calcium and integrin-binding protein 1 (CIB) (Calcium- and integrin-binding protein) (CIBP) (Calmyrin) (DNA-PKcs-interacting protein) (Kinase-interacting protein) (KIP) (SNK-interacting protein 2-28) (SIP2-28) |
| Target Name | calcium and integrin-binding protein 1 |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000185043 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99828 |
| Gene Card | CIB1 |
| Uniprot ID | Q99828 |
| Pfam | PF13499 |
| In ASD | no |
| Allosteric Prediction | no (-0.598686423) |
| Ortholog in Animals | Alpaca_ CIB1 ( ortholog_one2one ) Dog_ CIB1 ( ortholog_one2one ) GuineaPig_ CIB1 ( ortholog_one2one ) Macaque_ CIB1 ( ortholog_one2one ) Mouse_ Cib1 ( ortholog_one2one ) Pig_ CIB1 ( ortholog_one2one ) Rat_ Cib1 ( ortholog_one2one ) |
| Ohnologs | CIB3, CIB2 |
| Paralogs | CIB4, CHP1, CIB3, TESC, PPP3R1, CIB2, CHP2, PPP3R2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Expressed in the epidermis, hair follicles and keratinocytes (PubMed:30068544). Detected in platelets and in cell lines of megakaryocytic and erythrocytic lineages. Both isoform 1 and isoform 2 are detected in various cancer cell lines, with isoform 2 being the predominant form (at protein level). {ECO:0000269|PubMed:10477286, ECO:0000269|PubMed:11856312, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:9030514, ECO:0000269|PubMed:9372844}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1DGU (NMR - ) 1DGV (NMR - ) 1XO5 (X-ray 1.99A ) 1Y1A (X-ray 2.30A ) 2L4H (NMR - ) 2L4I (NMR - ) 2LM5 (NMR - ) 6OCX (X-ray 1.90A ) 6OD0 (X-ray 2.15A ) |
| DBSNP | rs3210935 rs11551250 |
| Subcellular location [CC] | Membrane; Lipid-anchor. Cell membrane, sarcolemma. Cell membrane. Apical cell membrane. Cell projection, ruffle membrane. Cell projection, filopodium tip. Cell projection, growth cone {ECO:0000269|PubMed:21215777}. Cell projection, lamellipodium {ECO:0000269|PubMed:21215777}. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Nucleus {ECO:0000269|PubMed:30068544}. Cell projection, neuron projection {ECO:0000269|PubMed:21215777}. Perikaryon {ECO:0000269|PubMed:21215777}. Note=Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic heart (By similarity). Colocalized with NBR1 to the perinuclear region. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Colocalized with RAC3 in the perinuclear area and at the cell periphery. Colocalized with PAK1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Redistributed to the cytoskeleton upon platelet aggregation. Translocates from the cytosol to the plasma membrane in a calcium-dependent manner. Colocalized with PLK3 at centrosomes in ductal breast carcinoma cells. {ECO:0000250}.; [Isoform 2]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:23503467}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23503467}. |
| Mouse PG classification | NA |
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