| Gene Information | |
|---|---|
| Gene Name | CHUK |
| Organism | Homo sapiens (Human) |
| Gene Length | 745 |
| Protein Names | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) |
| Target Name | inhibitor of nuclear factor kappa-b kinase alpha |
| Target Type | Literature-reported target |
| Gene Age | 810 ( ENSG00000213341 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15111 |
| Gene Card | CHUK |
| Uniprot ID | O15111 |
| Pfam | PF18397; PF12179; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (1.511652402) |
| Ortholog in Animals | Alpaca_ CHUK ( ortholog_one2one ) Dog_ CHUK ( ortholog_one2one ) GuineaPig_ CHUK ( ortholog_one2one ) Macaque_ CHUK ( ortholog_one2one ) Mouse_ Chuk ( ortholog_one2one ) Pig_ CHUK ( ortholog_one2one ) Rat_ Chuk ( ortholog_one2one ) Rabbit_ CHUK ( ortholog_one2one ) |
| Ohnologs | IKBKB |
| Paralogs | IKBKB, TBK1, IKBKE |
| Tissue | NA |
| Tissue Specificity | Widely expressed. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3BRT (X-ray 2.25A ) 5EBZ (X-ray 4.50A ) 5TQW (EM 5.60A ) 5TQX (EM 5.40A ) 5TQY (EM 5.20A ) |
| DBSNP | rs34427437 rs2230803 rs2230804 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:30341167}. Nucleus {ECO:0000269|PubMed:12789342}. Note=Shuttles between the cytoplasm and the nucleus. |
| Mouse PG classification | HPG |
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