| Gene Information | |
|---|---|
| Gene Name | HVEM |
| Organism | Homo sapiens (Human) |
| Gene Length | 283 |
| Protein Names | Tumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q92956 |
| Gene Card | TNFRSF14 |
| Uniprot ID | Q92956 |
| Pfam | PF00020 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with the highest expression in lung, spleen and thymus. Expressed in a subpopulation of B cells and monocytes (PubMed:18193050). Expressed in naive T cells (PubMed:19915044). {ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:19915044}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JMA (X-ray 2.65A ) 2AW2 (X-ray 2.80A ) 4FHQ (X-ray 2.25A ) 4RSU (X-ray 2.30A ) 5T2Q (X-ray 1.90A ) 5T2R (X-ray 2.10A ) 6NG3 (X-ray 2.88A ) 7MSG (X-ray 3.50A ) |
| DBSNP | rs4870 rs2234163 rs11573986 rs2234167 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19915044}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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