| Gene Information | |
|---|---|
| Gene Name | FZD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 565 |
| Protein Names | Frizzled-2 (Fz-2) (hFz2) (FzE2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000180340 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14332 |
| Gene Card | FZD2 |
| Uniprot ID | Q14332 |
| Pfam | PF01534; PF01392 |
| In ASD | no |
| Allosteric Prediction | yes (0.615425076) |
| Ortholog in Animals | Alpaca_ FZD2 ( ortholog_one2one ) Dog_ FZD2 ( ortholog_one2one ) GuineaPig_ FZD2 ( ortholog_one2one ) Macaque_ FZD2 ( ortholog_one2one ) Mouse_ Fzd2 ( ortholog_one2one ) Pig_ FZD2 ( ortholog_one2one ) Rat_ Fzd2 ( ortholog_one2one ) |
| Ohnologs | FZD3, FZD7, FZD1 |
| Paralogs | SFRP5, SFRP1, FZD5, FZD10, FZD9, SFRP4, FZD7, FRZB, FZD6, FZD8, SMO, FZD1, SFRP2, FZD4, FZD3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6C0B (X-ray 2.50A ) 7N95 (EM 4.10A ) 7N97 (EM 5.10A ) 7N9S (EM 5.10A ) |
| DBSNP | rs759024435 rs1223920489 rs1555657073 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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