Gene Information
Gene NameIMP5
OrganismHomo sapiens (Human)
Gene Length684
Protein NamesSignal peptide peptidase-like 2C (SPP-like 2C) (SPPL2c) (EC 3.4.23.-) (Intramembrane protease 5) (IMP-5)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ8IUH8
Gene CardSPPL2C
Uniprot IDQ8IUH8
PfamPF04258
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityHighly expressed in testis where it is primarily localised in spermatids (at protein level). {ECO:0000269|PubMed:32048434}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs17763658  rs242944  rs12185233  rs12185268  rs12373123  rs12373139  rs17852270  rs12373142  rs16940694 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:30733280, ECO:0000269|PubMed:32048434};
Multi-pass membrane protein {ECO:0000255};
Lumenal side {ECO:0000269|PubMed:15385547, ECO:0000269|PubMed:16829952}.
Mouse PG classificationNA
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