| Gene Information | |
|---|---|
| Gene Name | CHRNA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 457 |
| Protein Names | Acetylcholine receptor subunit alpha |
| Target Name | acetylcholine receptor subunit alpha |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000138435 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P02708 |
| Gene Card | CHRNA1 |
| Uniprot ID | P02708 |
| Pfam | PF02931; PF02932 |
| In ASD | yes |
| Allosteric Prediction | yes (1.118269983) |
| Ortholog in Animals | Alpaca_ CHRNA1 ( ortholog_one2one ) Dog_ CHRNA1 ( ortholog_one2one ) GuineaPig_ CHRNA1 ( ortholog_one2one ) Macaque_ CHRNA1 ( ortholog_one2one ) Mouse_ Chrna1 ( ortholog_one2one ) Pig_ CHRNA1 ( ortholog_one2one ) Rat_ Chrna1 ( ortholog_one2one ) Rabbit_ CHRNA1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA3, GABRA5, GLRA2, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB |
| Tissue | skeletal.muscle |
| Tissue Specificity | Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4ZJS (X-ray 2.23A ) 5HBT (X-ray 2.61A ) |
| DBSNP | rs137852807 rs137852801 rs137852799 rs137852809 rs137852798 rs137852805 rs137852803 rs137852800 rs137852806 rs137852802 rs137852804 rs6739001 rs137852808 |
| Subcellular location [CC] | Postsynaptic cell membrane {ECO:0000305|PubMed:27375219}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:27375219}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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