| Gene Information | |
|---|---|
| Gene Name | CHRM3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 590 |
| Protein Names | Muscarinic acetylcholine receptor M3 |
| Target Name | muscarinic acetylcholine receptor m3 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000133019 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P20309 |
| Gene Card | CHRM3 |
| Uniprot ID | P20309 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.18654137) |
| Ortholog in Animals | Alpaca_ CHRM3 ( ortholog_one2one ) GuineaPig_ Chrm3 ( ortholog_one2one ) Macaque_ CHRM3 ( ortholog_one2one ) Mouse_ Chrm3 ( ortholog_one2one ) Pig_ CHRM3 ( ortholog_one2one ) Rat_ Chrm3 ( ortholog_one2one ) Rabbit_ CHRM3 ( ortholog_one2one ) |
| Ohnologs | CHRM1, CHRM2, CHRM5 |
| Paralogs | HRH2, TAAR6, DRD4, HRH1, DRD1, GPR52, HTR1A, HTR1D, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, DRD3, GPR84, CHRM2, GPR161, DRD5, TAAR2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CSA (NMR - ) |
| DBSNP | rs2067481 rs16839102 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21056967}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15870063}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21056967}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane. {ECO:0000269|PubMed:21056967}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |