| Gene Information | |
|---|---|
| Gene Name | INCENP |
| Organism | Homo sapiens (Human) |
| Gene Length | 918 |
| Protein Names | Inner centromere protein |
| Target Name | inner centromere protein |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000149503 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9NQS7 |
| Gene Card | INCENP |
| Uniprot ID | Q9NQS7 |
| Pfam | PF03941; PF12178 |
| In ASD | no |
| Allosteric Prediction | yes (0.315321862) |
| Ortholog in Animals | Alpaca_ INCENP ( ortholog_one2one ) Dog_ INCENP ( ortholog_one2one ) GuineaPig_ INCENP ( ortholog_one2one ) Macaque_ INCENP ( ortholog_one2one ) Mouse_ Incenp ( ortholog_one2one ) Pig_ INCENP ( ortholog_one2one ) Rat_ Incenp ( ortholog_one2one ) Rabbit_ INCENP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2QFA (X-ray 1.40A ) 4AF3 (X-ray 2.75A ) 5IEH (X-ray 1.50A ) 5IEK (X-ray 1.80A ) 6GR8 (X-ray 1.75A ) 6GR9 (X-ray 2.25A ) 6YIE (X-ray 3.49A ) 6YIF (X-ray 1.81A ) 6YIH (X-ray 2.55A ) |
| DBSNP | rs1792947 rs12281503 rs34441559 rs2277283 rs7129085 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11453556}. Chromosome, centromere {ECO:0000269|PubMed:11453556, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11453556, ECO:0000269|PubMed:15316025}. Midbody {ECO:0000269|PubMed:15316025}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14610074}. Note=Colocalized at synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocenters. Colocalizes with AURKB at a connecting strand traversing the centromere region and joining sister kinetochores, in metaphase II centromeres. This strand disappears at the metaphase II/anaphase II transition and relocalizes to the spindle midzone (By similarity). Colocalizes with AURKB at mitotic chromosomes (PubMed:11453556). Localizes to inner kinetochore (PubMed:16760428). Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:15316025). Cocalizes to the equatorial cell cortex at anaphase (PubMed:11453556). {ECO:0000250|UniProtKB:Q9WU62, ECO:0000269|PubMed:11453556, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428}. |
| Mouse PG classification | NA |
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