| Gene Information | |
|---|---|
| Gene Name | CD27 |
| Organism | Homo sapiens (Human) |
| Gene Length | 260 |
| Protein Names | CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27) |
| Target Name | t-cell activation antigen cd27 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000139193 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P26842 |
| Gene Card | CD27 |
| Uniprot ID | P26842 |
| Pfam | PF00020 |
| In ASD | no |
| Allosteric Prediction | no (-0.523950488) |
| Ortholog in Animals | Alpaca_ CD27 ( ortholog_one2one ) Dog_ CD27 ( ortholog_one2one ) Mouse_ Cd27 ( ortholog_one2one ) Pig_ CD27 ( ortholog_one2one ) Rat_ Cd27 ( ortholog_one2one ) Rabbit_ CD27 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, TNFRSF6B, CD40, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, NGFR, FAS, TNFRSF10A, TNFRSF9, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B |
| Tissue | spleen |
| Tissue Specificity | Found in most T-lymphocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5TL5 (X-ray 1.80A ) 5TLJ (X-ray 3.50A ) 5TLK (X-ray 2.70A ) 7KX0 (X-ray 2.69A ) |
| DBSNP | rs397514667 rs25680 rs2532502 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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