Gene Information
Gene NameCHPF
OrganismHomo sapiens (Human)
Gene Length775
Protein NamesChondroitin sulfate synthase 2 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 2) (Chondroitin-polymerizing factor) (ChPF) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II) (N-acetylgalactosaminyltransferase 2)
Target NameNA
Target TypeNA
Gene Age886 ( ENSG00000123989 )
Evolutionary StageEumetazoa
AlphaFoldDBQ8IZ52
Gene CardCHPF
Uniprot IDQ8IZ52
PfamPF05679
In ASDno
Allosteric Predictionno (-1.464082428)
Ortholog in AnimalsAlpaca_ CHPF ( ortholog_one2one )
Dog_ CHPF ( ortholog_one2one )
GuineaPig_ CHPF ( ortholog_one2one )
Macaque_ CHPF ( ortholog_one2one )
Mouse_ Chpf ( ortholog_one2one )
Pig_ CHPF ( ortholog_one2one )
Rat_ Chpf ( ortholog_one2one )
Rabbit_ CHPF ( ortholog_one2one )
OhnologsCHPF2
ParalogsCHPF2, CHSY3, CHSY1, B4GALNT3, B4GALNT4, CSGALNACT2, CSGALNACT1
TissueNA
Tissue SpecificityUbiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. {ECO:0000269|PubMed:12716890, ECO:0000269|PubMed:12761225}.;
[Isoform 2]: Expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells. {ECO:0000269|PubMed:22082830}.;
[Isoform 3]: Also ubiquitous. {ECO:0000269|PubMed:22082830}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs6436155 
Subcellular location [CC][Isoform 1]: Golgi apparatus, Golgi stack membrane {ECO:0000305};
Single-pass type II membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:22082830}.;
[Isoform 3]: Cytoplasm, cytosol {ECO:0000269|PubMed:22082830}. Mitochondrion {ECO:0000269|PubMed:22082830}.;
[Isoform 2]: Mitochondrion matrix {ECO:0000269|PubMed:22082830}.
Mouse PG classificationNA
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