| Gene Information | |
|---|---|
| Gene Name | CHP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 196 |
| Protein Names | Calcineurin B homologous protein 2 (Hepatocellular carcinoma-associated antigen 520) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000166869 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43745 |
| Gene Card | CHP2 |
| Uniprot ID | O43745 |
| Pfam | PF13202; PF13499 |
| In ASD | no |
| Allosteric Prediction | no (-1.14091587) |
| Ortholog in Animals | Alpaca_ CHP2 ( ortholog_one2one ) Dog_ CHP2 ( ortholog_one2one ) GuineaPig_ CHP2 ( ortholog_one2one ) Macaque_ CHP2 ( ortholog_one2one ) Mouse_ Chp2 ( ortholog_one2one ) Pig_ CHP2 ( ortholog_one2one ) Rat_ Chp2 ( ortholog_one2one ) Rabbit_ CHP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CIB1, CIB4, CHP1, CIB3, TESC, PPP3R1, CIB2, PPP3R2 |
| Tissue | colon, duodenum, skin, small.intestine, rectum, lower.leg.skin, small.intestine.Peyers.patch, suprapubic.skin, transverse.colon |
| Tissue Specificity | Expressed in malignantly transformed cells but not detected in normal tissues. {ECO:0000269|PubMed:12097419, ECO:0000269|PubMed:12226101}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2BEC (X-ray 2.70A ) |
| DBSNP | rs35641939 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21392185}. Cytoplasm {ECO:0000269|PubMed:21392185}. Cell membrane {ECO:0000269|PubMed:21392185}. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. {ECO:0000250}. |
| Mouse PG classification | NA |
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