| Gene Information | |
|---|---|
| Gene Name | CHMP4B |
| Organism | Homo sapiens (Human) |
| Gene Length | 224 |
| Protein Names | Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000101421 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H444 |
| Gene Card | CHMP4B |
| Uniprot ID | Q9H444 |
| Pfam | PF03357 |
| In ASD | no |
| Allosteric Prediction | no (-0.95159789) |
| Ortholog in Animals | Alpaca_ CHMP4B ( ortholog_one2one ) Dog_ CHMP4B ( ortholog_one2one ) GuineaPig_ CHMP4B ( ortholog_one2one ) Macaque_ CHMP4B ( ortholog_one2one ) Mouse_ Chmp4b ( ortholog_one2one ) Pig_ CHMP4B ( ortholog_one2one ) Rat_ Chmp4b ( ortholog_one2many ) Rat_ Chmp4bl1 ( ortholog_one2many ) |
| Ohnologs | CHMP4C |
| Paralogs | CHMP5, CHMP4A, CHMP7, CHMP4C |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed at higher level in heart and skeletal muscle. Also expressed in brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes. {ECO:0000269|PubMed:14678797}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.200571(Mouse);0.638822(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3C3Q (X-ray 2.10A ) 3UM3 (X-ray 3.80A ) 4ABM (X-ray 1.80A ) 5MK2 (X-ray 1.70A ) |
| DBSNP | rs118203965 rs118203966 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:15511219}. Late endosome membrane {ECO:0000269|PubMed:15511219, ECO:0000305|PubMed:12860994}; Peripheral membrane protein {ECO:0000305}. Midbody {ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22422861}. Nucleus envelope {ECO:0000269|PubMed:26040712}. Note=Recruited to the nuclear envelope by CHMP7 during late anaphase (PubMed:26040712). Localizes transiently to the midbody arms immediately before abscission (PubMed:22422861). {ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:26040712}. |
| Mouse PG classification | NA |
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