| Gene Information | |
|---|---|
| Gene Name | CBL |
| Organism | Homo sapiens (Human) |
| Gene Length | 906 |
| Protein Names | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000110395 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P22681 |
| Gene Card | CBL |
| Uniprot ID | P22681 |
| Pfam | PF02262; PF02761; PF02762; PF00627 |
| In ASD | no |
| Allosteric Prediction | yes (1.503476889) |
| Ortholog in Animals | Alpaca_ CBL ( ortholog_one2one ) Dog_ CBL ( ortholog_one2one ) GuineaPig_ CBL ( ortholog_one2one ) Macaque_ CBL ( ortholog_one2one ) Mouse_ Cbl ( ortholog_one2one ) Pig_ CBL ( ortholog_one2one ) Rat_ Cbl ( ortholog_one2one ) Rabbit_ CBL ( ortholog_one2one ) |
| Ohnologs | CBLC, CBLB |
| Paralogs | CBLB, CBLC |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.103432(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1B47 (X-ray 2.20A ) 1FBV (X-ray 2.90A ) 1YVH (X-ray 2.05A ) 2CBL (X-ray 2.10A ) 2JUJ (NMR - ) 2K4D (NMR - ) 2OO9 (X-ray 2.10A ) 2Y1M (X-ray 2.67A ) 2Y1N (X-ray 2.00A ) 3BUM (X-ray 2.00A ) 3BUN (X-ray 2.00A ) 3BUO (X-ray 2.60A ) 3BUW (X-ray 1.45A ) 3BUX (X-ray 1.35A ) 3OB1 (X-ray 2.20A ) 3OB2 (X-ray 2.10A ) 3PLF (X-ray 1.92A ) 4A49 (X-ray 2.21A ) 4A4B (X-ray 2.79A ) 4A4C (X-ray 2.70A ) 4GPL (X-ray 3.00A ) 5HKW (X-ray 2.25A ) 5HKX (X-ray 1.85A ) 5HKY (X-ray 1.80A ) 5HKZ (X-ray 1.80A ) 5HL0 (X-ray 2.20A ) 5J3X (X-ray 2.82A ) 5O76 (X-ray 2.47A ) 6O02 (X-ray 2.95A ) 6O03 (X-ray 3.30A ) 6XAR (X-ray 2.50A ) |
| DBSNP | rs267606704 rs267606706 rs267606705 rs267606707 rs267606708 rs2227988 rs2229073 rs17122769 |
| Subcellular location [CC] | Cytoplasm. Cell membrane. Cell projection, cilium {ECO:0000269|PubMed:29237719}. Golgi apparatus {ECO:0000269|PubMed:29237719}. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane. |
| Mouse PG classification | LPG |
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