| Gene Information | |
|---|---|
| Gene Name | KB37 |
| Organism | Homo sapiens (Human) |
| Gene Length | 529 |
| Protein Names | Keratin, type II cytoskeletal 74 (Cytokeratin-74) (CK-74) (Keratin-5c) (K5C) (Keratin-74) (K74) (Type II inner root sheath-specific keratin-K6irs4) (Type-II keratin Kb37) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q7RTS7 |
| Gene Card | KRT74 |
| Uniprot ID | Q7RTS7 |
| Pfam | PF00038; PF16208 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS Huxley layer, but not in Henle layer or cuticle of the IRS. In the IRS Huxley layer, it is expressed in specialized Huxley cells, termed 'Fluegelzellen, along the area of differentiated Henle cells (at protein level). {ECO:0000269|PubMed:12648212, ECO:0000269|PubMed:16874310, ECO:0000269|PubMed:24714551}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs267607205 rs11170177 rs11170176 rs670741 rs147962513 rs57387512 rs57711382 rs267607477 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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