| Gene Information | |
|---|---|
| Gene Name | CHIP |
| Organism | Homo sapiens (Human) |
| Gene Length | 303 |
| Protein Names | E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UNE7 |
| Gene Card | STUB1 |
| Uniprot ID | Q9UNE7 |
| Pfam | PF18391; PF04564 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in differentiated myotubes (at protein level) (PubMed:17369820). Highly expressed in skeletal muscle, heart, pancreas, brain and placenta (PubMed:10330192, PubMed:11435423). Detected in kidney, liver and lung (PubMed:10330192, PubMed:11435423). {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:17369820}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.008497(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4KBQ (X-ray 2.91A ) 6EFK (X-ray 1.50A ) 6NSV (X-ray 1.30A ) 7TB1 (X-ray 1.78A ) |
| DBSNP | rs690016544 rs587777347 rs587777346 rs587777344 rs587777341 rs146251364 rs587777342 rs587777340 rs587777345 rs587777343 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:23973223}. Nucleus {ECO:0000269|PubMed:23973223}. Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg). {ECO:0000269|PubMed:23973223}. |
| Mouse PG classification | NA |
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