| Gene Information | |
|---|---|
| Gene Name | TNFSF13 |
| Organism | Homo sapiens (Human) |
| Gene Length | 250 |
| Protein Names | Tumor necrosis factor ligand superfamily member 13 (A proliferation-inducing ligand) (APRIL) (TNF- and APOL-related leukocyte expressed ligand 2) (TALL-2) (TNF-related death ligand 1) (TRDL-1) (CD antigen CD256) |
| Target Name | a proliferation-inducing ligand |
| Target Type | Clinical trial target |
| Gene Age | 244 ( ENSG00000161955 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O75888 |
| Gene Card | TNFSF13 |
| Uniprot ID | O75888 |
| Pfam | PF00229 |
| In ASD | no |
| Allosteric Prediction | no (-0.481449233) |
| Ortholog in Animals | Alpaca_ TNFSF13 ( ortholog_one2one ) Dog_ TNFSF13 ( ortholog_one2one ) GuineaPig_ TNFSF13 ( ortholog_one2one ) Mouse_ Tnfsf13 ( ortholog_one2one ) Pig_ TNFSF13 ( ortholog_one2one ) Rat_ Tnfsf13 ( ortholog_one2one ) Rabbit_ TNFSF13 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFSF12, TNFSF13B |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4ZCH (X-ray 2.43A ) |
| DBSNP | rs11552708 rs3803800 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:11571266}. |
| Mouse PG classification | NA |
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