| Gene Information | |
|---|---|
| Gene Name | CHIA |
| Organism | Homo sapiens (Human) |
| Gene Length | 476 |
| Protein Names | Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000134216 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9BZP6 |
| Gene Card | CHIA |
| Uniprot ID | Q9BZP6 |
| Pfam | PF01607; PF00704 |
| In ASD | no |
| Allosteric Prediction | yes (0.012217434) |
| Ortholog in Animals | Alpaca_ CHIA ( ortholog_one2one ) Dog_ CHIA ( ortholog_one2one ) Macaque_ CHIA ( ortholog_one2one ) Mouse_ Chil4 ( ortholog_one2many ) Mouse_ Chil6 ( ortholog_one2many ) Mouse_ Chil3 ( ortholog_one2many ) Mouse_ Chia1 ( ortholog_one2many ) Mouse_ Chil5 ( ortholog_one2many ) Pig_ CHIA ( ortholog_one2one ) Rat_ AABR07012788.1 ( ortholog_one2many ) Rat_ Chia ( ortholog_one2many ) Rat_ RGD1309110 ( ortholog_one2many ) Rat_ Chi3l3 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | CHID1, CHIT1, CTBS, CHI3L1, OVGP1, CHI3L2 |
| Tissue | stomach |
| Tissue Specificity | Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:15192232}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2YBT (X-ray 2.22A ) 2YBU (X-ray 2.25A ) 3FXY (X-ray 2.00A ) 3FY1 (X-ray 1.70A ) 3RM4 (X-ray 1.90A ) 3RM8 (X-ray 1.80A ) 3RM9 (X-ray 2.10A ) 3RME (X-ray 1.80A ) |
| DBSNP | rs41282492 rs41282494 rs41282496 rs3818822 rs61756687 rs2256721 rs2275253 rs2275254 rs36011905 rs2256721 |
| Subcellular location [CC] | [Isoform 1]: Secreted. Note=Secretion depends on EGFR activity.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm. |
| Mouse PG classification | NA |
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