| Gene Information | |
|---|---|
| Gene Name | CHGA |
| Organism | Homo sapiens (Human) |
| Gene Length | 457 |
| Protein Names | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000100604 ) 3 ( ENSG00000276781 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P10645 |
| Gene Card | CHGA |
| Uniprot ID | P10645 |
| Pfam | PF01271 |
| In ASD | no |
| Allosteric Prediction | yes (0.179742152) |
| Ortholog in Animals | Alpaca_ CHGA ( ortholog_one2one ) GuineaPig_ CHGA ( ortholog_one2one ) Macaque_ CHGA ( ortholog_one2one ) Mouse_ Chga ( ortholog_one2one ) Pig_ CHGA ( ortholog_one2one ) Rat_ Chga ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CHGB |
| Tissue | NA |
| Tissue Specificity | GE-25 is found in the brain. {ECO:0000269|PubMed:7535395}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.100000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1LV4 (NMR - ) 6R2X (NMR - ) |
| DBSNP | rs3742712 rs9658654 rs9658655 rs9658662 rs9658663 rs9658664 rs9658665 rs2228575 rs9658667 rs9658668 rs9658669 rs729940 |
| Subcellular location [CC] | [Serpinin]: Secreted {ECO:0000250|UniProtKB:P26339}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P26339}. Note=Pyroglutaminated serpinin localizes to secretory vesicle. {ECO:0000250|UniProtKB:P26339}.; Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P10354}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle {ECO:0000250|UniProtKB:P10354}. Secreted {ECO:0000250|UniProtKB:P10354}. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. In pituitary gonadotropes, located in large secretory granules. {ECO:0000250|UniProtKB:P10354}. |
| Mouse PG classification | NA |
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