| Gene Information | |
|---|---|
| Gene Name | CHD7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2997 |
| Protein Names | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.12) (ATP-dependent helicase CHD7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000171316 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | NA |
| Gene Card | CHD7 |
| Uniprot ID | Q9P2D1 |
| Pfam | PF07533; PF00385; PF00271; PF00176 |
| In ASD | no |
| Allosteric Prediction | no (-0.390028857) |
| Ortholog in Animals | Alpaca_ CHD7 ( ortholog_one2one ) Dog_ CHD7 ( ortholog_one2one ) GuineaPig_ CHD7 ( ortholog_one2one ) Macaque_ CHD7 ( ortholog_one2one ) Mouse_ Chd7 ( ortholog_one2one ) Pig_ CHD7 ( ortholog_one2one ) Rat_ Chd7 ( ortholog_one2one ) Rabbit_ CHD7 ( ortholog_one2one ) |
| Ohnologs | CHD8, CHD6, CHD9 |
| Paralogs | CHD8, SMARCA1, RAD54B, HLTF, HELLS, SHPRH, BTAF1, ZRANB3, SMARCA5, TTF2, SMARCA2, CHD9, SMARCAL1, CHD1L, CHD3, RAD54L2, SMARCAD1, CHD4, ATRX, INO80, CHD6, SRCAP, CHD1, CHD2, RAD54L, EP400, ERCC6, ERCC6L, CHD5, SMARCA4 |
| Tissue | NA |
| Tissue Specificity | Widely expressed in fetal and adult tissues. {ECO:0000269|PubMed:15300250, ECO:0000269|PubMed:22646239}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.0125(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CKC (NMR - ) 2V0E (NMR - ) 2V0F (NMR - ) |
| DBSNP | rs1416709395 rs756851968 rs121434345 rs767819417 rs1355349547 rs398124317 rs779024959 rs41272435 rs372110761 rs61742851 rs764496155 rs200898742 rs200898742 rs1554581354 rs61995713 rs41305525 rs766747354 rs772369092 rs71640285 rs142962579 rs78962949 rs746837682 rs529321177 rs756365280 rs141947938 rs202208393 rs61978638 rs121434344 rs772260091 rs377662366 rs1165711448 rs763978472 rs370194460 rs117506164 rs587783435 rs768481542 rs1057521077 rs121434338 rs886041167 rs1804098617 rs1586393556 rs886040988 rs121434339 rs864309609 rs1563643394 rs373301291 rs1563644113 rs770166812 rs773187713 rs886040993 rs61737194 rs1554602465 rs759918327 rs201423234 rs1013310877 rs886063038 rs1197494895 rs201083157 rs587783451 rs794727555 rs121434343 rs758409717 rs61753399 rs374408098 rs200806228 rs121434341 rs121434341 rs77704609 rs541818422 rs41315633 rs398124324 rs755492299 rs547209998 rs192129249 rs747082615 rs201319489 rs1373315351 rs113877656 rs370231679 rs3750308 rs775132352 rs200140270 rs45521933 rs113938624 rs370271088 rs1467824778 rs184814820 |
| Subcellular location [CC] | [Isoform 1]: Nucleus {ECO:0000269|PubMed:20453063}.; [Isoform 3]: Nucleus, nucleolus {ECO:0000269|PubMed:22646239}. |
| Mouse PG classification | NA |
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