| Gene Information | |
|---|---|
| Gene Name | CHD4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1912 |
| Protein Names | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000111642 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14839 |
| Gene Card | CHD4 |
| Uniprot ID | Q14839 |
| Pfam | PF08074; PF06461; PF08073; PF00385; PF06465; PF00271; PF00628; PF00176 |
| In ASD | yes |
| Allosteric Prediction | yes (0.771497735) |
| Ortholog in Animals | Alpaca_ CHD4 ( ortholog_one2one ) Dog_ CHD4 ( ortholog_one2one ) GuineaPig_ CHD4 ( ortholog_one2one ) Macaque_ CHD4 ( ortholog_one2one ) Mouse_ Chd4 ( ortholog_one2one ) Pig_ CHD4 ( ortholog_one2one ) Rat_ Chd4 ( ortholog_one2one ) Rabbit_ CHD4 ( ortholog_one2one ) |
| Ohnologs | CHD3, CHD5 |
| Paralogs | SMARCA1, RAD54B, HLTF, HELLS, SHPRH, BTAF1, ZRANB3, SMARCA5, TTF2, SMARCA2, CHD9, SMARCAL1, CHD1L, CHD3, RAD54L2, SMARCAD1, ATRX, INO80, CHD6, SRCAP, CHD1, CHD2, RAD54L, CHD7, CHD8, EP400, ERCC6, ERCC6L, CHD5, SMARCA4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1MM2 (NMR - ) 1MM3 (NMR - ) 2EE1 (NMR - ) 2L5U (NMR - ) 2L75 (NMR - ) 2N5N (NMR - ) 4O9I (X-ray 2.60A ) 6BGG (NMR - ) 6Q3M (X-ray 2.52A ) 6RYR (EM 3.10A ) 6RYU (EM 4.00A ) |
| DBSNP | rs1639122 rs886039916 rs886039915 rs886039917 rs886039919 rs886039918 rs201992075 rs35512811 rs16932768 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27616479}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17626165}. Note=Associates with centrosomes in interphase. {ECO:0000250|UniProtKB:Q6PDQ2}. |
| Mouse PG classification | NA |
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