| Gene Information | |
|---|---|
| Gene Name | CHD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1710 |
| Protein Names | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000153922 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O14646 |
| Gene Card | CHD1 |
| Uniprot ID | O14646 |
| Pfam | PF18375; PF00385; PF13907; PF00271; PF00176 |
| In ASD | no |
| Allosteric Prediction | yes (0.549520838) |
| Ortholog in Animals | Alpaca_ CHD1 ( ortholog_one2one ) Dog_ CHD1 ( ortholog_one2one ) GuineaPig_ CHD1 ( ortholog_one2one ) Macaque_ CHD1 ( ortholog_one2one ) Mouse_ Chd1 ( ortholog_one2one ) Pig_ CHD1 ( ortholog_one2one ) Rat_ Chd1 ( ortholog_one2one ) Rabbit_ CHD1 ( ortholog_one2one ) |
| Ohnologs | CHD2 |
| Paralogs | SMARCA1, RAD54B, HLTF, HELLS, SHPRH, BTAF1, ZRANB3, SMARCA5, TTF2, SMARCA2, CHD9, SMARCAL1, CHD1L, CHD3, RAD54L2, SMARCAD1, CHD4, ATRX, INO80, CHD6, SRCAP, CHD2, RAD54L, CHD7, CHD8, EP400, ERCC6, ERCC6L, CHD5, SMARCA4 |
| Tissue | NA |
| Tissue Specificity | Expressed in many tissues including in the brain, where the highest level of expression is found in the cerebellum and basal ganglia. {ECO:0000269|PubMed:28866611}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001779(Rat);0.035897(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2B2T (X-ray 2.45A ) 2B2U (X-ray 2.95A ) 2B2V (X-ray 2.65A ) 2B2W (X-ray 2.40A ) 2B2Y (X-ray 2.35A ) 2N39 (NMR - ) 4B4C (X-ray 1.62A ) 4NW2 (X-ray 1.90A ) 4O42 (X-ray 1.87A ) 5AFW (X-ray 1.60A ) |
| DBSNP | rs1064795875 rs10062803 rs1554078856 rs1554078349 rs1293161341 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:P40201}. Cytoplasm {ECO:0000250|UniProtKB:P40201}. Note=Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis. {ECO:0000250|UniProtKB:P40201}. |
| Mouse PG classification | NA |
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