| Gene Information | |
|---|---|
| Gene Name | ARHGEF6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 776 |
| Protein Names | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000129675 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15052 |
| Gene Card | ARHGEF6 |
| Uniprot ID | Q15052 |
| Pfam | PF16523; PF00307; PF00169; PF00621; PF07653 |
| In ASD | no |
| Allosteric Prediction | no (-0.600783917) |
| Ortholog in Animals | Alpaca_ ARHGEF6 ( ortholog_one2one ) Dog_ ARHGEF6 ( ortholog_one2one ) GuineaPig_ ARHGEF6 ( ortholog_one2one ) Macaque_ ARHGEF6 ( ortholog_one2one ) Mouse_ Arhgef6 ( ortholog_one2one ) Pig_ ARHGEF6 ( ortholog_one2one ) Rat_ Arhgef6 ( ortholog_one2one ) Rabbit_ ARHGEF6 ( ortholog_one2one ) |
| Ohnologs | ARHGEF7 |
| Paralogs | MCF2L2, VAV1, PLEKHN1, PLEKHG4, TIAM2, ARHGEF40, ARHGEF25, VAV2, VAV3, SPATA13, ARHGEF9, PLEKHG1, SESTD1, PLEKHG2, KIAA1755, PLEKHG4B, TIAM1, MCF2, KALRN, ARHGEF7, MCF2L, TRIO |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1UJY (NMR - ) 1WYR (NMR - ) |
| DBSNP | rs5974620 |
| Subcellular location [CC] | Cell projection, lamellipodium {ECO:0000250}. |
| Mouse PG classification | LPG |
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