| Gene Information | |
|---|---|
| Gene Name | SLC17A3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 420 |
| Protein Names | Sodium-dependent phosphate transport protein 4 (Na(+)/PI cotransporter 4) (NPT4) (Sodium/phosphate cotransporter 4) (Solute carrier family 17 member 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000124564 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O00476 |
| Gene Card | SLC17A3 |
| Uniprot ID | O00476 |
| Pfam | PF07690 |
| In ASD | no |
| Allosteric Prediction | no (-0.169303381) |
| Ortholog in Animals | Alpaca_ SLC17A3 ( ortholog_one2one ) Dog_ SLC17A3 ( ortholog_one2one ) Macaque_ SLC17A3 ( ortholog_one2one ) Mouse_ Slc17a3 ( ortholog_one2one ) Pig_ SLC17A3 ( ortholog_one2one ) Rat_ Slc17a3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLC17A8, SLC37A4, SLC17A6, SLC17A7, SLC17A9, SLC17A2, SLC37A1, SLC17A1, SLC37A3, SLC17A5, SLC37A2, SLC17A4 |
| Tissue | kidney, liver |
| Tissue Specificity | Expressed in the liver and kidney (PubMed:9149941, PubMed:20810651). It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level) (PubMed:20810651). {ECO:0000269|PubMed:20810651, ECO:0000269|PubMed:9149941}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs387907257 rs1165165 rs56027330 rs387907256 rs11966370 |
| Subcellular location [CC] | [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15505377}; Multi-pass membrane protein {ECO:0000269|PubMed:15505377}.; [Isoform 2]: Cell membrane {ECO:0000269|PubMed:20810651}; Multi-pass membrane protein {ECO:0000269|PubMed:20810651}. |
| Mouse PG classification | NA |
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