| Gene Information | |
|---|---|
| Gene Name | LYPD6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 171 |
| Protein Names | Ly6/PLAUR domain-containing protein 6 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000187123 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q86Y78 |
| Gene Card | LYPD6 |
| Uniprot ID | Q86Y78 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.937955129) |
| Ortholog in Animals | Alpaca_ LYPD6 ( ortholog_one2one ) Dog_ LYPD6 ( ortholog_one2one ) GuineaPig_ LYPD6 ( ortholog_one2one ) Macaque_ LYPD6 ( ortholog_one2one ) Mouse_ Lypd6 ( ortholog_one2one ) Pig_ LYPD6 ( ortholog_one2one ) Rat_ Lypd6 ( ortholog_one2one ) Rabbit_ LYPD6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LYPD6B |
| Tissue | NA |
| Tissue Specificity | Detected in the temporal cortex (at protein level) (PubMed:25680266). Ubiquitous (PubMed:19653121). Highly expressed in brain and heart (PubMed:19653121). {ECO:0000269|PubMed:19653121, ECO:0000269|PubMed:25680266}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6GBI (X-ray 1.25A ) 6IB6 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:19653121}. Cell membrane {ECO:0000269|PubMed:25680266}; Lipid-anchor, GPI-anchor {ECO:0000255}. Synapse, synaptosome {ECO:0000250|UniProtKB:D3ZTT2}. Membrane raft {ECO:0000250|UniProtKB:Q66IA6}. Cell projection, dendrite {ECO:0000250|UniProtKB:D3ZTT2}. Perikaryon {ECO:0000250|UniProtKB:D3ZTT2}. Note=Colocalizes with alpha-3:beta-4- and alpha-7- nicotinic acetylcholine receptors (nAChRs) in the primary cortex and hippocampus. {ECO:0000250|UniProtKB:D3ZTT2}. |
| Mouse PG classification | NA |
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