| Gene Information | |
|---|---|
| Gene Name | G2E3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 706 |
| Protein Names | G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000092140 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7L622 |
| Gene Card | G2E3 |
| Uniprot ID | Q7L622 |
| Pfam | PF00632 |
| In ASD | no |
| Allosteric Prediction | no (-1.332081375) |
| Ortholog in Animals | Alpaca_ G2E3 ( ortholog_one2one ) Dog_ G2E3 ( ortholog_one2one ) GuineaPig_ G2E3 ( ortholog_one2one ) Macaque_ G2E3 ( ortholog_one2one ) Mouse_ G2e3 ( ortholog_one2one ) Pig_ G2E3 ( ortholog_one2one ) Rat_ G2e3 ( ortholog_one2one ) Rabbit_ G2E3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PHF7, PHF11, PHF6 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in brain, liver, kidney, testes and ovary. {ECO:0000269|PubMed:10718198}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17096934 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:17239372}. Cytoplasm {ECO:0000269|PubMed:17239372}. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage. {ECO:0000269|PubMed:17239372}. |
| Mouse PG classification | NA |
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