Gene Information | |
---|---|
Gene Name | CGN |
Organism | Homo sapiens (Human) |
Gene Length | 1203 |
Protein Names | Cingulin |
Target Name | NA |
Target Type | NA |
Gene Age | 3 ( ENSG00000143375 ) |
Evolutionary Stage | Cellular_organisms |
AlphaFoldDB | Q9P2M7 |
Gene Card | CGN |
Uniprot ID | Q9P2M7 |
Pfam | PF01576 |
In ASD | no |
Allosteric Prediction | no (-0.195441486) |
Ortholog in Animals | GuineaPig_ CGN ( ortholog_one2one ) Mouse_ Cgn ( ortholog_one2one ) |
Ohnologs | CGNL1 |
Paralogs | CGNL1, MYO3A, MYH10, TMF1, MYO7B, MYO1D, CCDC102B, MYH1, MYO19, MYO1C, MYH3, MYH7, MYO1A, MYO15A, MYH9, MYO18A, MYO1E, MYH14, MYH2, MYH15, MYO3B, CCDC102A, MYO5A, MYO1G, MYO1H, MYO18B, MYO5C, MYO9B, MYO7A, MYH7B, MYO5B, MYH11, MYO16, MYO10, MYH8, MYH6, MYO9A, MYO6, MYH4, CCDC158, MYO1B, MYO1F, MYH13 |
Tissue | NA |
Tissue Specificity | Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart. |
Pharmacological Animal Models | NA |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | NA |
DBSNP | rs12038198 |
Subcellular location [CC] | Cell junction, tight junction {ECO:0000250|UniProtKB:P59242}. Note=Localizes to the apical junction complex composed of tight and adherens junctions (By similarity). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (PubMed:12023291). {ECO:0000250|UniProtKB:P59242, ECO:0000269|PubMed:12023291}. |
Mouse PG classification | NA |
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