Gene Information
Gene NameCGN
OrganismHomo sapiens (Human)
Gene Length1203
Protein NamesCingulin
Target NameNA
Target TypeNA
Gene Age3 ( ENSG00000143375 )
Evolutionary StageCellular_organisms
AlphaFoldDBQ9P2M7
Gene CardCGN
Uniprot IDQ9P2M7
PfamPF01576
In ASDno
Allosteric Predictionno (-0.195441486)
Ortholog in AnimalsGuineaPig_ CGN ( ortholog_one2one )
Mouse_ Cgn ( ortholog_one2one )
OhnologsCGNL1
ParalogsCGNL1, MYO3A, MYH10, TMF1, MYO7B, MYO1D, CCDC102B, MYH1, MYO19, MYO1C, MYH3, MYH7, MYO1A, MYO15A, MYH9, MYO18A, MYO1E, MYH14, MYH2, MYH15, MYO3B, CCDC102A, MYO5A, MYO1G, MYO1H, MYO18B, MYO5C, MYO9B, MYO7A, MYH7B, MYO5B, MYH11, MYO16, MYO10, MYH8, MYH6, MYO9A, MYO6, MYH4, CCDC158, MYO1B, MYO1F, MYH13
TissueNA
Tissue SpecificityLocalized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs12038198 
Subcellular location [CC]Cell junction, tight junction {ECO:0000250|UniProtKB:P59242}. Note=Localizes to the apical junction complex composed of tight and adherens junctions (By similarity). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (PubMed:12023291). {ECO:0000250|UniProtKB:P59242, ECO:0000269|PubMed:12023291}.
Mouse PG classificationNA
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