| Gene Information | |
|---|---|
| Gene Name | CFL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 166 |
| Protein Names | Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform) |
| Target Name | cofilin-1 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000172757 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P23528 |
| Gene Card | CFL1 |
| Uniprot ID | P23528 |
| Pfam | PF00241 |
| In ASD | no |
| Allosteric Prediction | yes (0.606125573) |
| Ortholog in Animals | Alpaca_ CFL1 ( ortholog_one2one ) Dog_ CFL1 ( ortholog_one2many ) Rat_ AABR07029863.4 ( ortholog_one2one ) |
| Ohnologs | DSTN, CFL2 |
| Paralogs | CFL2, DSTN |
| Tissue | NA |
| Tissue Specificity | Widely distributed in various tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Q8G (NMR - ) 1Q8X (NMR - ) 3J0S (EM 9.00A ) 4BEX (X-ray 2.80A ) 5HVK (X-ray 3.50A ) 5L6W (X-ray 2.53A ) 6UBY (EM 7.50A ) 6UC0 (EM 7.50A ) 6UC4 (EM 9.20A ) 6VAO (EM 3.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus matrix {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P18760}. Cell projection, growth cone {ECO:0000250|UniProtKB:P18760}. Cell projection, axon {ECO:0000250|UniProtKB:P18760}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide. |
| Mouse PG classification | NA |
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