| Gene Information | |
|---|---|
| Gene Name | CFH |
| Organism | Homo sapiens (Human) |
| Gene Length | 1231 |
| Protein Names | Complement factor H (H factor 1) |
| Target Name | complement factor h |
| Target Type | Clinical trial target |
| Gene Age | 78 ( ENSG00000000971 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P08603 |
| Gene Card | CFH |
| Uniprot ID | P08603 |
| Pfam | PF00084 |
| In ASD | no |
| Allosteric Prediction | yes (0.722137892) |
| Ortholog in Animals | Alpaca_ CFH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2, CFHR3 |
| Tissue | NA |
| Tissue Specificity | Expressed in the retinal pigment epithelium (at protein level) (PubMed:25136834). CFH is one of the most abundant complement components in blood where the liver is the major source of CFH protein in vivo. in addition, CFH is secreted by additional cell types including monocytes, fibroblasts, or endothelial cells (PubMed:6444659, PubMed:2968404, PubMed:2139673, PubMed:25136834). {ECO:0000269|PubMed:2139673, ECO:0000269|PubMed:25136834, ECO:0000269|PubMed:2968404, ECO:0000269|PubMed:6444659}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1HAQ (X-ray - ) 1HCC (NMR - ) 1HFH (NMR - ) 1HFI (NMR - ) 2BZM (NMR - ) 2G7I (X-ray 1.75A ) 2IC4 (X-ray - ) 2JGW (NMR - ) 2JGX (NMR - ) 2KMS (NMR - ) 2QFG (X-ray - ) 2QFH (X-ray - ) 2RLP (NMR - ) 2RLQ (NMR - ) 2UWN (X-ray 2.35A ) 2V8E (X-ray 2.50A ) 2W80 (X-ray 2.35A ) 2W81 (X-ray 2.35A ) 2WII (X-ray 2.70A ) 2XQW (X-ray 2.31A ) 3GAU (X-ray - ) 3GAV (X-ray - ) 3GAW (X-ray - ) 3KXV (X-ray 2.00A ) 3KZJ (X-ray 1.65A ) 3OXU (X-ray 2.10A ) 3R62 (X-ray 1.52A ) 3RJ3 (X-ray 2.35A ) 3SW0 (X-ray 1.80A ) 4AYD (X-ray 2.40A ) 4AYE (X-ray 2.80A ) 4AYI (X-ray 2.31A ) 4AYM (X-ray 3.00A ) 4B2R (NMR - ) 4B2S (NMR - ) 4J38 (X-ray 2.83A ) 4K12 (X-ray 1.08A ) 4ONT (X-ray 2.15A ) 4ZH1 (X-ray 2.24A ) 5NBQ (X-ray 3.18A ) 5O32 (X-ray 4.21A ) 5O35 (X-ray 4.20A ) 5WTB (X-ray 3.30A ) 6ATG (X-ray 1.80A ) 6ZH1 (X-ray 2.20A ) |
| DBSNP | rs800292 rs121913058 rs201671665 rs1061170 rs121913056 rs1061171 rs121913052 rs35453854 rs757756991 rs148165372 rs1391815797 rs762443267 rs515299 rs1573076722 rs1065489 rs149474608 rs777049051 rs145975787 rs121913053 rs17575212 rs534399 rs11539862 rs34362004 rs35274867 rs35343172 rs62625015 rs121913062 rs575109631 rs15809 rs121913055 rs460897 rs761877050 rs460184 rs121913059 rs121913051 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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