| Gene Information | |
|---|---|
| Gene Name | CFD |
| Organism | Homo sapiens (Human) |
| Gene Length | 253 |
| Protein Names | Complement factor D (EC 3.4.21.46) (Adipsin) (C3 convertase activator) (Properdin factor D) |
| Target Name | complement factor d |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000197766 ) 3 ( ENSG00000274619 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P00746 |
| Gene Card | CFD |
| Uniprot ID | P00746 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.26077824) |
| Ortholog in Animals | Alpaca_ CFD ( ortholog_one2one ) Dog_ ARHGAP45 ( ortholog_one2one ) GuineaPig_ CFD ( ortholog_one2one ) Macaque_ CFD ( ortholog_one2one ) Mouse_ Cfd ( ortholog_one2one ) Pig_ CFD ( ortholog_one2one ) Rat_ Cfd ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HGFAC, F7, C1R, KLK10, F9, F12, F10, CFI, PRSS55, PRSS51, C1S, C1RL, HP, HPR, KLKB1, F11 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BIO (X-ray 1.50A ) 1DFP (X-ray 2.40A ) 1DIC (X-ray 1.80A ) 1DST (X-ray 2.00A ) 1DSU (X-ray 2.00A ) 1FDP (X-ray 2.10A ) 1HFD (X-ray 2.30A ) 2XW9 (X-ray 1.20A ) 2XWA (X-ray 2.80A ) 2XWB (X-ray 3.49A ) 4CBN (X-ray 1.80A ) 4CBO (X-ray 1.80A ) 4D9R (X-ray 2.42A ) 5FBE (X-ray 1.43A ) 5FBI (X-ray 1.47A ) 5FCK (X-ray 1.86A ) 5MT0 (X-ray 1.29A ) 5MT4 (X-ray 1.65A ) 5NAR (X-ray 1.55A ) 5NAT (X-ray 1.17A ) 5NAW (X-ray 1.25A ) 5NB6 (X-ray 1.75A ) 5NB7 (X-ray 1.33A ) 5NBA (X-ray 1.87A ) 5TCA (X-ray 3.15A ) 5TCC (X-ray 3.37A ) 6FTY (X-ray 1.67A ) 6FTZ (X-ray 1.67A ) 6FUG (X-ray 2.21A ) 6FUH (X-ray 1.37A ) 6FUI (X-ray 1.38A ) 6FUJ (X-ray 2.25A ) 6FUT (X-ray 1.50A ) 6QMR (X-ray 2.00A ) 6QMT (X-ray 1.80A ) 6VMJ (X-ray 2.95A ) 6VMK (X-ray 3.01A ) |
| DBSNP | rs267606720 rs267606721 rs2230216 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
| click here to return to the previous page | |