Gene Information
Gene NameCFD
OrganismHomo sapiens (Human)
Gene Length253
Protein NamesComplement factor D (EC 3.4.21.46) (Adipsin) (C3 convertase activator) (Properdin factor D)
Target Namecomplement factor d
Target TypeClinical trial target
Gene Age382 ( ENSG00000197766 )
3 ( ENSG00000274619 )
Evolutionary StageEumetazoa
AlphaFoldDBP00746
Gene CardCFD
Uniprot IDP00746
PfamPF00089
In ASDno
Allosteric Predictionyes (0.26077824)
Ortholog in AnimalsAlpaca_ CFD ( ortholog_one2one )
Dog_ ARHGAP45 ( ortholog_one2one )
GuineaPig_ CFD ( ortholog_one2one )
Macaque_ CFD ( ortholog_one2one )
Mouse_ Cfd ( ortholog_one2one )
Pig_ CFD ( ortholog_one2one )
Rat_ Cfd ( ortholog_one2one )
OhnologsNA
ParalogsHGFAC, F7, C1R, KLK10, F9, F12, F10, CFI, PRSS55, PRSS51, C1S, C1RL, HP, HPR, KLKB1, F11
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1BIO  (X-ray  1.50A  1DFP  (X-ray  2.40A  1DIC  (X-ray  1.80A  1DST  (X-ray  2.00A  1DSU  (X-ray  2.00A  1FDP  (X-ray  2.10A  1HFD  (X-ray  2.30A  2XW9  (X-ray  1.20A  2XWA  (X-ray  2.80A  2XWB  (X-ray  3.49A  4CBN  (X-ray  1.80A  4CBO  (X-ray  1.80A  4D9R  (X-ray  2.42A  5FBE  (X-ray  1.43A  5FBI  (X-ray  1.47A  5FCK  (X-ray  1.86A  5MT0  (X-ray  1.29A  5MT4  (X-ray  1.65A  5NAR  (X-ray  1.55A  5NAT  (X-ray  1.17A  5NAW  (X-ray  1.25A  5NB6  (X-ray  1.75A  5NB7  (X-ray  1.33A  5NBA  (X-ray  1.87A  5TCA  (X-ray  3.15A  5TCC  (X-ray  3.37A  6FTY  (X-ray  1.67A  6FTZ  (X-ray  1.67A  6FUG  (X-ray  2.21A  6FUH  (X-ray  1.37A  6FUI  (X-ray  1.38A  6FUJ  (X-ray  2.25A  6FUT  (X-ray  1.50A  6QMR  (X-ray  2.00A  6QMT  (X-ray  1.80A  6VMJ  (X-ray  2.95A  6VMK  (X-ray  3.01A 
DBSNP rs267606720  rs267606721  rs2230216 
Subcellular location [CC]Secreted.
Mouse PG classificationNA
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