| Gene Information | |
|---|---|
| Gene Name | BCO2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 579 |
| Protein Names | Carotenoid-cleaving dioxygenase, mitochondrial (EC 1.13.11.-) (EC 1.13.11.71) (B-diox-II) (Beta,beta-carotene 9',10'-oxygenase) (Beta-carotene dioxygenase 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000197580 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9BYV7 |
| Gene Card | BCO2 |
| Uniprot ID | Q9BYV7 |
| Pfam | PF03055 |
| In ASD | no |
| Allosteric Prediction | no (-0.764484472) |
| Ortholog in Animals | Alpaca_ BCO2 ( ortholog_one2one ) Dog_ PTS ( ortholog_one2one ) GuineaPig_ BCO2 ( ortholog_one2one ) Macaque_ BCO2 ( ortholog_one2one ) Mouse_ Bco2 ( ortholog_one2one ) Pig_ BCO2 ( ortholog_one2one ) Rat_ Bco2 ( ortholog_one2one ) Rabbit_ BCO2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BCO1, RPE65 |
| Tissue | adrenal.gland, heart, liver |
| Tissue Specificity | Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level). {ECO:0000269|PubMed:15983114}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs10891338 rs17113607 rs2217401 |
| Subcellular location [CC] | Mitochondrion {ECO:0000250|UniProtKB:Q99NF1}. |
| Mouse PG classification | NA |
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