Gene Information
Gene NameCFAP251
OrganismHomo sapiens (Human)
Gene Length1149
Protein NamesCilia- and flagella-associated protein 251 (WD repeat-containing protein 66)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000158023 )
Evolutionary StageEukaryota
AlphaFoldDBQ8TBY9
Gene CardCFAP251
Uniprot IDQ8TBY9
PfamPF00400
In ASDno
Allosteric Predictionno (-1.240455066)
Ortholog in AnimalsAlpaca_ CFAP251 ( ortholog_one2one )
Dog_ CFAP251 ( ortholog_one2one )
Mouse_ Wdr66 ( ortholog_one2one )
Rabbit_ CFAP251 ( ortholog_one2one )
OhnologsNA
ParalogsWDR90, CFAP52, CFAP44, EML5, EML3, EML6, EML1, EML2, EML4
TissueNA
Tissue SpecificityIsoform 1 is highly expressed in testis and, at lower levels, in lung. Very low levels are detected in kidney and brain (PubMed:30122540). In testis, expressed in spermatozoa (at protein level) (PubMed:30122540, PubMed:30122541). Isoform 2 is not detected in testis, lung, kidney, nor in brain (PubMed:30122540). {ECO:0000269|PubMed:30122540, ECO:0000269|PubMed:30122541}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs12824001  rs12824001  rs199671406  rs34768683  rs11043265 
Subcellular location [CC]Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A8IRK7}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:30122540, ECO:0000269|PubMed:30122541}.
Mouse PG classificationNA
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