| Gene Information | |
|---|---|
| Gene Name | CES2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 559 |
| Protein Names | Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000172831 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O00748 |
| Gene Card | CES2 |
| Uniprot ID | O00748 |
| Pfam | PF00135 |
| In ASD | no |
| Allosteric Prediction | yes (0.269692549) |
| Ortholog in Animals | Alpaca_ CES2 ( ortholog_one2one ) Dog_ CES2 ( ortholog_one2one ) Macaque_ CES2 ( ortholog_one2one ) Mouse_ Ces2f ( ortholog_one2many ) Mouse_ Ces2c ( ortholog_one2many ) Mouse_ Ces2e ( ortholog_one2many ) Mouse_ Ces2b ( ortholog_one2many ) Mouse_ Ces2g ( ortholog_one2many ) Mouse_ Ces2a ( ortholog_one2many ) Rat_ Ces2a ( ortholog_one2many ) Rat_ Ces2g ( ortholog_one2many ) Rat_ Ces2i ( ortholog_one2many ) Rat_ Ces2b ( ortholog_one2many ) Rat_ Ces2c ( ortholog_one2many ) Rat_ Ces2j ( ortholog_one2many ) Rat_ AABR07007146.1 ( ortholog_one2many ) Rat_ Ces2e ( ortholog_one2many ) Rat_ AABR07042565.1 ( ortholog_one2many ) Rat_ Ces2f ( ortholog_one2many ) |
| Ohnologs | NLGN2 |
| Paralogs | NLGN2, ACHE, NLGN4X, NLGN4Y, CES3, NLGN1, CES5A, CES4A, BCHE, TG, NLGN3, CES1, CEL |
| Tissue | NA |
| Tissue Specificity | Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum. {ECO:0000269|PubMed:9144407}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs72547531 rs8192924 |
| Subcellular location [CC] | Endoplasmic reticulum lumen {ECO:0000269|PubMed:22446793}. |
| Mouse PG classification | NA |
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