| Gene Information | |
|---|---|
| Gene Name | CES1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 567 |
| Protein Names | Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cholesteryl ester hydrolase) (CEH) (EC 3.1.1.13) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH) |
| Target Name | liver carboxylesterase 1 |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000198848 ) 3 ( ENSG00000262243 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P23141 |
| Gene Card | CES1 |
| Uniprot ID | P23141 |
| Pfam | PF00135 |
| In ASD | no |
| Allosteric Prediction | yes (0.778909321) |
| Ortholog in Animals | Alpaca_ CES1 ( ortholog_one2one ) Macaque_ CES1 ( ortholog_one2one ) Mouse_ Ces1g ( ortholog_one2many ) Mouse_ Ces1h ( ortholog_one2many ) Mouse_ Ces1c ( ortholog_one2many ) Mouse_ Ces1b ( ortholog_one2many ) Mouse_ Ces1d ( ortholog_one2many ) Pig_ CES1 ( ortholog_one2one ) Rat_ Cesl1 ( ortholog_one2many ) Rat_ Ces1d ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | NLGN2, ACHE, NLGN4X, NLGN4Y, CES3, NLGN1, CES2, CES5A, CES4A, BCHE, TG, NLGN3, CEL |
| Tissue | NA |
| Tissue Specificity | Expressed predominantly in liver with lower levels in heart and lung (PubMed:10562416). Expressed in macrophages (PubMed:11015575, PubMed:21049984, PubMed:18762277). {ECO:0000269|PubMed:10562416, ECO:0000269|PubMed:11015575, ECO:0000269|PubMed:18762277, ECO:0000269|PubMed:21049984}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1MX1 (X-ray 2.40A ) 1MX5 (X-ray 2.80A ) 1MX9 (X-ray 2.90A ) 1YA4 (X-ray 3.20A ) 1YA8 (X-ray 3.00A ) 1YAH (X-ray 3.00A ) 1YAJ (X-ray 3.20A ) 2DQY (X-ray 3.00A ) 2DQZ (X-ray 2.80A ) 2DR0 (X-ray 3.20A ) 2H7C (X-ray 2.00A ) 2HRQ (X-ray 2.70A ) 2HRR (X-ray 2.70A ) 3K9B (X-ray 3.10A ) 4AB1 (X-ray 2.20A ) 5A7F (X-ray 1.86A ) 5A7G (X-ray 1.48A ) 5A7H (X-ray 2.01A ) |
| DBSNP | rs2307240 rs71647871 rs2307243 rs2307227 |
| Subcellular location [CC] | Endoplasmic reticulum lumen {ECO:0000269|PubMed:10562416}. Cytoplasm {ECO:0000269|PubMed:16024911}. Lipid droplet {ECO:0000269|PubMed:16024911}. Note=Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the droplets and hydrolyzes cholesteryl esters more efficiently from mixed droplets. {ECO:0000269|PubMed:16024911}. |
| Mouse PG classification | NA |
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