| Gene Information | |
|---|---|
| Gene Name | CASH |
| Organism | Homo sapiens (Human) |
| Gene Length | 480 |
| Protein Names | CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O15519 |
| Gene Card | CFLAR |
| Uniprot ID | O15519 |
| Pfam | PF01335 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001942(Rat);0.06121(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2N5R (NMR - ) 3H11 (X-ray 1.90A ) 3H13 (X-ray 2.20A ) 6M6O (NMR - ) 7DEE (NMR - ) 7LXC (NMR - ) |
| DBSNP | rs13424615 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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