| Gene Information | |
|---|---|
| Gene Name | CERKL |
| Organism | Homo sapiens (Human) |
| Gene Length | 558 |
| Protein Names | Ceramide kinase-like protein |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000188452 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q49MI3 |
| Gene Card | CERKL |
| Uniprot ID | Q49MI3 |
| Pfam | PF19280; PF00781 |
| In ASD | no |
| Allosteric Prediction | no (-0.980402045) |
| Ortholog in Animals | Alpaca_ CERKL ( ortholog_one2one ) Dog_ CERKL ( ortholog_one2one ) Macaque_ CERKL ( ortholog_one2one ) Mouse_ Cerkl ( ortholog_one2one ) Pig_ CERKL ( ortholog_one2one ) Rat_ Cerkl ( ortholog_one2one ) Rabbit_ CERKL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CERK, SPHK1, SPHK2, AGK |
| Tissue | cerebellum |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in adult retina, liver and pancreas as well as in fetal brain, lung and kidney. Isoform 3 is expressed in adult retina as well as in fetal lung and liver. Isoform 4 is expressed in adult retina, lung and kidney as well as in fetal lung and liver. Moderately expressed in retina, kidney, lung, testis, trachea, and pancreas. Weakly expressed in brain, placenta and liver. {ECO:0000269|PubMed:14681825, ECO:0000269|PubMed:15708351, ECO:0000269|PubMed:19158957}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs569826109 rs10185262 rs35955809 |
| Subcellular location [CC] | Cytoplasm. Nucleus, nucleolus. Note=Enriched in nucleoli. May shuttle between nucleus and cytoplasm. Isoform 5 is not enriched in the nucleoli.; [Isoform 2]: Cytoplasm. Nucleus, nucleolus. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. |
| Mouse PG classification | NA |
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