| Gene Information | |
|---|---|
| Gene Name | RETSAT |
| Organism | Homo sapiens (Human) |
| Gene Length | 610 |
| Protein Names | All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein) |
| Target Name | all-trans-retinol 13,14-reductase |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000042445 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q6NUM9 |
| Gene Card | RETSAT |
| Uniprot ID | Q6NUM9 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.240907338) |
| Ortholog in Animals | Alpaca_ RETSAT ( ortholog_one2one ) Dog_ RETSAT ( ortholog_one2one ) GuineaPig_ RETSAT ( ortholog_one2one ) Macaque_ RETSAT ( ortholog_one2one ) Mouse_ Retsat ( ortholog_one2one ) Pig_ RETSAT ( ortholog_one2one ) Rat_ Retsat ( ortholog_one2one ) Rabbit_ RETSAT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BLOC1S2, PYROXD2 |
| Tissue | NA |
| Tissue Specificity | Expressed in liver; expression positively correlates with obesity and liver steatosis (PubMed:28855500). Expressed in adipose tissue; expression tends to be decreased in obese versus lean individuals (PubMed:19139408). {ECO:0000269|PubMed:19139408, ECO:0000269|PubMed:28855500}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4832169 rs4832168 rs13384912 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64FW2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64FW2}. |
| Mouse PG classification | NA |
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