| Gene Information | |
|---|---|
| Gene Name | APLN |
| Organism | Homo sapiens (Human) |
| Gene Length | 77 |
| Protein Names | Apelin (APJ endogenous ligand) [Cleaved into: Apelin-36; Apelin-31; Apelin-28; Apelin-13] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000171388 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9ULZ1 |
| Gene Card | APLN |
| Uniprot ID | Q9ULZ1 |
| Pfam | PF15360 |
| In ASD | no |
| Allosteric Prediction | no (-0.776898812) |
| Ortholog in Animals | Dog_ APLN ( ortholog_one2one ) GuineaPig_ APLN ( ortholog_one2one ) Mouse_ Apln ( ortholog_one2one ) Pig_ APLN ( ortholog_one2one ) Rabbit_ APLN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | placenta |
| Tissue Specificity | Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain (PubMed:10617103). Secreted by the mammary gland into the colostrum and the milk. {ECO:0000269|PubMed:10617103}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000250|UniProtKB:Q9TUI9}. Secreted, extracellular space {ECO:0000250|UniProtKB:Q9TUI9}. Note=Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk. {ECO:0000250|UniProtKB:Q9TUI9}. |
| Mouse PG classification | NA |
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