Gene Information
Gene NamePRAME
OrganismHomo sapiens (Human)
Gene Length509
Protein NamesMelanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma)
Target Nametumor expressed melanoma antigen
Target TypeClinical trial target
Gene Age645 ( ENSG00000185686 )
3 ( ENSG00000275013 )
Evolutionary StageMammalia
AlphaFoldDBP78395
Gene CardPRAME
Uniprot IDP78395
PfamNA
In ASDno
Allosteric Predictionno (-0.882683436)
Ortholog in AnimalsAlpaca_ PRAME ( ortholog_one2one )
Dog_ PRAME ( ortholog_one2one )
Macaque_ PRAME ( ortholog_one2one )
Pig_ PRAME ( ortholog_one2one )
OhnologsNA
ParalogsPRAMEF10, PRAMEF8, PRAMEF26, PRAMEF5, PRAMEF12, PRAMEF33, PRAMEF17, PRAMEF27, PRAMEF19, PRAMEF4, PRAMEF9, PRAMEF6, PRAMEF15, PRAMEF20, PRAMEF14, PRAMEF7, PRAMEF2, PRAMEF25, PRAMEF13, PRAMEF18, PRAMEF1, PRAMEF11, LRRC14, LRRC14B
Tissuetestis
Tissue SpecificityExpressed in testis. Detected in samples of kidney, brain and skin. {ECO:0000269|PubMed:9047241}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs1129172  rs41277507 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:23460923, ECO:0000305|PubMed:16620968}. Chromosome {ECO:0000269|PubMed:21822215}. Cytoplasm {ECO:0000269|PubMed:23460923}. Golgi apparatus {ECO:0000269|PubMed:23460923}. Cell membrane {ECO:0000269|PubMed:16620968}. Note=Associates with chromatin;
specifically enriched at transcriptionally active promoters that are also bound by nuclear transcription factor Y (composed of NFYA, NFYB and NFYC) and at enhancers (PubMed:21822215). Recruited to the Golgi apparatus in response to interferon gamma (IFNG) treatment (PubMed:23460923). {ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:23460923}.
Mouse PG classificationNA
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