| Gene Information | |
|---|---|
| Gene Name | PLA2G6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 806 |
| Protein Names | 85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (2-lysophosphatidylcholine acylhydrolase) (EC 3.1.1.5) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9) |
| Target Name | 85/88 kda calcium-independent phospholipase a2 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000184381 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60733 |
| Gene Card | PLA2G6 |
| Uniprot ID | O60733 |
| Pfam | PF00023; PF12796; PF13857; PF01734 |
| In ASD | no |
| Allosteric Prediction | yes (1.223759872) |
| Ortholog in Animals | Alpaca_ PLA2G6 ( ortholog_one2one ) Dog_ PLA2G6 ( ortholog_one2one ) GuineaPig_ PLA2G6 ( ortholog_one2one ) Macaque_ PLA2G6 ( ortholog_one2one ) Mouse_ Pla2g6 ( ortholog_one2one ) Pig_ PLA2G6 ( ortholog_one2one ) Rat_ Pla2g6 ( ortholog_one2one ) Rabbit_ PLA2G6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ANKRD22, TONSL, NFKBIB, NFKBIA |
| Tissue | NA |
| Tissue Specificity | Four different transcripts were found to be expressed in a distinct tissue distribution. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11570605 rs11570606 rs11570607 rs11570646 rs121908682 rs11570680 rs121908681 rs1004616610 rs121908683 rs767689496 rs121908686 rs121908687 rs34184838 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18208975}. Cell membrane {ECO:0000269|PubMed:18208975}. Mitochondrion {ECO:0000250|UniProtKB:P97819}. Cell projection, pseudopodium {ECO:0000269|PubMed:18208975}. Note=Recruited to the membrane-enriched pseudopods upon MCP1/CCL2 stimulation in monocytes. {ECO:0000269|PubMed:18208975}. |
| Mouse PG classification | NA |
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