Gene Information
Gene NameCEP250
OrganismHomo sapiens (Human)
Gene Length2442
Protein NamesCentrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2)
Target NameNA
Target TypeNA
Gene Age810 ( ENSG00000126001 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ9BV73
Gene CardCEP250
Uniprot IDQ9BV73
PfamNA
In ASDno
Allosteric Predictionno (-0.239097379)
Ortholog in AnimalsAlpaca_ CEP250 ( ortholog_one2one )
Dog_ CEP250 ( ortholog_one2one )
Macaque_ CEP250 ( ortholog_one2one )
Mouse_ Cep250 ( ortholog_one2one )
Pig_ CEP250 ( ortholog_one2one )
Rat_ Cep250 ( ortholog_one2one )
Rabbit_ CEP250 ( ortholog_one2one )
OhnologsCROCC, GCC2
ParalogsCEP135, CROCC2, TSGA10, CROCC
TissueNA
Tissue SpecificityUbiquitously and weakly expressed.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6OQA  (X-ray  2.20A  ) 
DBSNP rs145878385  rs2296403  rs17092706  rs3748433 
Subcellular location [CC]Cytoplasm, perinuclear region {ECO:0000269|PubMed:9647649}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26337392, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:9647649}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:31974111}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:9647649}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q60952}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q60952}. Note=Component of the core centrosome. In interphase cells, it specifically associates with the proximal ends of both mother and daughter centrioles. Associates with the centrosome in interphase cells. In mitotic cells, it dissociates from the mitotic spindle poles. At the end of cell division, it reaccumulates at centrosomes.
Mouse PG classificationNA
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