Gene Information
Gene NameCEP131
OrganismHomo sapiens (Human)
Gene Length1083
Protein NamesCentrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000141577 )
Evolutionary StageEukaryota
AlphaFoldDBQ9UPN4
Gene CardCEP131
Uniprot IDQ9UPN4
PfamNA
In ASDno
Allosteric Predictionyes (0.04817951)
Ortholog in AnimalsAlpaca_ CEP131 ( ortholog_one2one )
Dog_ CEP131 ( ortholog_one2one )
GuineaPig_ CEP131 ( ortholog_one2one )
Macaque_ CEP131 ( ortholog_one2one )
Mouse_ Cep131 ( ortholog_one2one )
Pig_ CEP131 ( ortholog_one2one )
Rat_ Cep131 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs8067409  rs752612451  rs2466773  rs2659015  rs2659016 
Subcellular location [CC]Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:27224062, ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30804208}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208, ECO:0000269|PubMed:31789463}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30804208}. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q62036}. Note=Colocalized with pericentriolar material protein PCM1 at centriolar satellites. During spermiogenesis, becomes enriched with nephrocystin NPHP1 at the transition zone, a structure at the base of the ciliary axoneme important for regulating traffic into the ciliary compartment. Traffics towards and away from the centrosome/basal body and the transition zone of the ciliary axoneme in a microtubule-dependent manner. Localized at the Golgi-derived acrosome and the centrosome-containing head-tail coupling apparatus (HTCA) (By similarity). Ubiquitinated form is sequestered and colocalized with BBS4, CEP290, PCM1 and PCNT at centriolar satellites in proliferating cells. Colocalized with the pericentriolar material protein PCM1 at centrosome. Traffics towards and away from centriolar satellites and centrosome in a microtubule- and dynein-dependent manner in interphase cells. Displaced from centriolar satellites but still remains associated with the centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAPK signaling (PubMed:26616734). {ECO:0000250, ECO:0000269|PubMed:26616734}.
Mouse PG classificationNA
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