| Gene Information | |
|---|---|
| Gene Name | TLE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 770 |
| Protein Names | Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000196781 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q04724 |
| Gene Card | TLE1 |
| Uniprot ID | Q04724 |
| Pfam | PF03920; PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.485768485) |
| Ortholog in Animals | Alpaca_ TLE1 ( ortholog_one2one ) Dog_ TLE1 ( ortholog_one2one ) GuineaPig_ TLE1 ( ortholog_one2one ) Macaque_ TLE1 ( ortholog_one2one ) Mouse_ Tle1 ( ortholog_one2one ) Pig_ TLE1 ( ortholog_one2one ) Rat_ Tle1 ( ortholog_one2one ) |
| Ohnologs | TLE2, TLE3 |
| Paralogs | TLE4, TLE6, TLE5, TLE7, TLE2, TLE3 |
| Tissue | NA |
| Tissue Specificity | In all tissues examined, mostly in brain, liver and muscle. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);0.025641(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GXR (X-ray 1.65A ) 2CE8 (X-ray 2.03A ) 2CE9 (X-ray 2.12A ) 4OM2 (X-ray 4.00A ) 4OM3 (X-ray 2.86A ) 5MWJ (X-ray 2.04A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12397081}. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components. |
| Mouse PG classification | NA |
| click here to return to the previous page | |